Bioavailability of curcumin

Curcumin exhibits low oral bioavailability and may undergo intestinal metabolism;
absorbed curcumin undergoes rapid first-pass metabolism and excretion in the bile.

In vivo studies show that less than 1% of the curcumin one consumes actually makes it into the bloodstream, and the liver rapidly destroys most of this. 

In order  to increase the bioavailability of Curcumin one has to inhibit the enzymes responsible
for the transformation of curcumin to inactive substances.
Encapsulated curcumin with added enzyme inhibitors increase its bioactivity over a longer
time-period compared to the free Curcumin.

Curcumin absorption and bioavailability

Curcumin dosage

Turmeric has been consumed on daily basis as a spice and healing herb.
A traditional daily dosage for an adult was up to 10 grams of dry Turmeric as part of a herbal remedy decoction. 
This daily dosage supposedly provides about 350mg of Curcumin and other compounds.

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